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Viagra for women: how does the pill work

Finally, gender inequality in this matter is over. In pharmacies, a female analogue of Viagra, the drug Flibanserin (Addyi), has appeared, which is able to treat premenopausal hypolibemia. And to put it simply, it can cause sexual desire in women.

“Addyi” vs Viagra

Viagra has been a lifesaver for men with erectile dysfunction for many years, but it was not prescribed for women. At least officially. Of course, you will not find this drug in clinical guidelines, but women have some experience of using Viagra. However, its effectiveness is rather controversial and all positive results are associated solely with physical arousal, which is not a determining factor in the treatment of hypolibemia, the cause and clinic of which is much more complicated.

For example, one study involved more than 200 women. As a result of taking Viagra, they all really noted the appearance of arousal, the release of vaginal lubrication and the presence of orgasms during sex. But they did not have an increase in desire or the appearance of pleasure during sexual intercourse. But this is the main problem in women with hypolibemia. Sexual intercourse is not a problem for them, physiologically women are able to have sex, but there is no desire.

Therefore, something else was clearly required, suitable specifically for the female sex. Especially since many women would like to start taking drugs like Viagra. After all, sexual desire also decreases with age, or against the background of stress, or due to chronic diseases such as diabetes or multiple sclerosis.

womans viagra Addyi (Flibanserin)

womans viagra Addyi (Flibanserin)

Statistics tell us that about 10% of adult women suffer from hypolibemia. This is manifested by one or more symptoms:

  • Absence or insufficient number of sexual fantasies or thoughts about sex;
  • Lack or insufficient response to sexual stimulation;
  • Loss of interest in sexual activity;
  • Anxiety due to loss of arousal or interest in sex;

How flibanserin works

Just as Viagra was originally developed for the treatment of cardiac ischemia, Addyi, according to the intention of the manufacturers, was supposed to become an antidepressant. But, as it turned out, the drug copes well with hypolibemia. The only thing I don’t understand is how he does it.

Flibanserin, when taken regularly, is known to increase the levels of dopamine and norepinephrine in the blood, these hormones are known to increase sexual desire and arousal. sexual intercourse. This is a good indicator for an antidepressant, because it helps keep emotions in check, but it reduces sexual satisfaction.

The drug begins to work after four weeks after taking it. It is recommended to take flibanserin at night at 100 mg. During the day, taking the medicine is not desirable because it causes drowsiness and increases the risk of pressure drop and fainting. The medicine can be drunk with or without food, but food enhances systemic absorption.

The effectiveness of the drug

To confirm the effectiveness of the drug in premenopausal women, clinical trials were conducted in three stages. In total, the trials lasted 18 months and data were collected from 11,000 women.

The trials involved women from 18 years of age to menopause who were not taking hormones, antiarrhythmic drugs, beta blockers, CNS stimulants, anticoagulants, dopamine antagonists, muscle relaxants, benzodiazepines, sedatives, antidepressants, antipsychotics, antiepileptic drugs, yohimbine, metoclopramide, triptans, narcotics . Those who had undergone psychotherapy in the past 3 months were also excluded from the study.

If we discard those subjects who were given a placebo, then of the remaining about 40-60% of the participants noted that their condition improved or significantly improved. This is a very good indicator, which is comparable to the results of Viagra.

A study was also conducted in women after menopause and it gave the same results.

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Addyi (Flibanserin)
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Addyi medication

Addyi is a medication that is used to treat low sexual desire in women. It contains the active ingredients flibanserin and bupropion, which work together to increase sexual desire.
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Female Cialis is a long-acting oral medication which immediately enhances quality of sex experience for women, the Cialis contains active pharmaceutical ingredient, Tadalafil.Female Cialis works by increasing genital blood flow to women, which, in turn, increases the pleasure that is experienced when having intercourse.
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Side effects and precautions

The most common side effects are:

  • Sedation (do not forget that it was developed as an antidepressant);
  • Dizziness;
  • insomnia;
  • Nausea;
  • dry mouth;
  • Feeling tired;
  • Patients with liver disease should take with caution because it can cause hypotension (low blood pressure) and loss of consciousness;

Be sure to tell your doctor about all medications you are taking before starting a course of flibanserin. It is not compatible with substances such as:

  • It is contraindicated to use together with alcohol (not earlier than two hours before taking the drug).¬†Studies say that you can drink no more than 350 ml of beer, 150 g of wine and 40 g of vodka;
  • Do not take with CYP3A4 inhibitors, which include certain antibiotics (particularly macrolides), antifungals, antivirals, and grapefruit juice;
  • Verapamil and diltiazem;
  • Medicines for the treatment of hepatitis C;
  • Antibiotics ciprofloxacin and erythromycin;
  • fluconazole and itraconazole;
  • Antiretrovirals (used to treat HIV): ritonavir and indinavir;
  • The antidepressant nefazodone;
  • St. John’s wort and gingko biloba;
  • It is worth taking the drug with caution if you drink oral contraceptives.¬†In such cases, a higher dose of flibanserin is required, which means an increased risk of side effects;

Do not drive a car or other machinery for at least 6 hours after taking the drug.

There is no evidence that the drug adversely affects the development of the fetus during pregnancy or lactation.

“Addyi” and alcohol

As much as you would like to combine the use of a drug that enhances sexual desire with alcohol, manufacturers strongly advise against doing this, stating that this increases the risk of loss of consciousness and hypotension.

If you took an evening dose of the drug, then you can only drink alcohol in the morning.¬†And no later than two hours before taking the drug, otherwise it is better to skip today’s dose altogether.¬†And, if you miss a dose, don’t make up for it by taking a double dose.¬†Just wait until the time of admission and drink the usual amount of medicine prescribed by the doctor.

Registration problems

The main problem was the side effects. There were fears that they were much more serious than the likely benefits of the drug. In addition, it was not clear how exactly to approach the treatment. Sexual desire depends on both physical and physiological factors.

Addyi and Viagra work differently. Sildenafil does not increase sexual arousal in men, while flibanserin increases dopamine and norepinephrine levels, leading to increased desire and arousal. That is, one drug treats the physical aspect of sexual dysfunction, while the other is aimed at a more complex issue – the feeling of arousal. But in the end, they nevertheless decided that side effects, with a reasonable approach, can be completely controlled.

Conclusion

A low level of sexual desire, unfortunately, is not such a rare guest in a woman’s bed.¬†The cause can be both serious chronic diseases and constant stress.¬†Viagra does not give guaranteed good results in women, and it does not help patients with hypolibemia.

However, when taking the drug “Addyi” there is a steady improvement, the appearance of desire and excitement. Therefore, it is recommended by doctors for the treatment of decreased sexual desire of any etiology. This medicine is available in tablets and requires constant intake. An alternative is the injectable Vileese (Bremelanotide), which is injected as needed.

 

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