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Pletal (Cilostazol) is a prescription medication used to improve the ability of people with intermittent claudication (pain, cramping, or weakness in the legs brought on by walking that goes away after a short rest) to walk.


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Pletal – Cilostazol – 50mg/100mg

  • Brand: Pletoz
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  • Disease: Intermittent Claudication

It is not known how Pletal works but it may improve blood flow and oxygen delivery to the muscles.

Pletal comes as an oral tablet. It is usually taken twice a day with food for 12 weeks and then once daily. If you are taking Pletal for claudication, your doctor will likely have you stop smoking and may also have you take aspirin or another anti-platelet medication.

Common side effects of Pletal include headache, diarrhea, nausea, vomiting, muscle pain, and heartburn. Do not drink alcohol while taking Pletal as it can increase your risk of liver damage

Frequently asked Questions

When should Pletal be stopped before surgery?

It is used to improve walking distance in patients with peripheral artery disease (PAD). Pletal has been shown to improve blood flow and muscle oxygenation, as well as reduce pain. It can be used alone or in combination with other therapies, such as angioplasty or surgery.

How long does it take for Pletal to work?

Claudication is pain in the leg that occurs with exercise and is relieved by rest. The drug was approved for use in the United States by the Food and Drug Administration on July 26, 2002.

The mechanism of action of cilostazol has not been fully elucidated; however, it is known to inhibit phosphodiesterase III (PDEIII), resulting in an increase in cyclic adenosine monophosphate (cAMP) levels. cAMP has multiple effects on vascular smooth muscle cells, including inhibition of platelet aggregation and promotion of vasodilation. These mechanisms may account for the beneficial effects of cilostazol seen in patients with intermittent claudication.

Cilostazol appears to be safe and well tolerated; common adverse effects include headache, diarrhea, nausea/vomiting, and myalgia/arthralgia. There have been reports of serious adverse events associated with its use; however these are rare and generally occur only in patients who are also taking other medications that may interact with cilostazol

Why is Pletal contraindicated in heart failure?

It is used to treat people with claudication, which is pain in the legs caused by poor blood circulation. Pletal can help increase walking distance and improve quality of life.

What happens if I stop taking Pletal?

It is used to treat a condition called intermittent claudication, which is when you have pain, cramping, or discomfort in your legs or feet because of poor blood flow. Pletal can help improve your ability to walk and do other activities.

Does Pletal increase bleeding?

Claudication is pain or discomfort in the leg that occurs during exercise and is relieved by rest. The cause of claudication is a narrowing (stenosis) of the arteries supplying blood to the leg muscles. This narrowing reduces blood flow and oxygen delivery to these muscles, leading to pain or discomfort. Cilostazol works by relaxing and widening these narrowed arteries, improving blood flow and oxygen delivery to the muscles.

Cilostazol has been shown in clinical trials to improve walking distance in people with intermittent claudication by an average of 43%. In addition, cilostazol can also help reduce symptoms such as cramping, heaviness, tiredness, or burning sensations in the feet and legs associated with claudication.

Cilostazol is available as tablets (50 mg) that are taken twice daily (100 mg/day). It should be taken at least 30 minutes before breakfast and dinner. Cilostazol may not be suitable for everyone so it’s important that you speak with your doctor if you think it may be right for you.

Can Plavix and Pletal be given together?

The recommended dose of Pletal is 100 mg twice daily. In clinical trials, Pletal was found to improve walking distance and pain-free walking time in patients with intermittent claudication.

The mechanism by which cilostazol improves symptoms in patients with intermittent claudication is not fully understood, but it is thought that cilostazol increases blood flow through the arteries and reduces platelet aggregation. Cilostazol has also been shown to improve endothelial function and reduce inflammation.

Pletal may cause adverse effects such as headache, diarrhea, nausea, and vomiting. Patients should be advised to report any signs or symptoms of an allergic reaction immediately after taking Pletal, including rash, hives, swelling of the lips or tongue), difficulty breathing or swallowing).

What are the side effects of Pletal?

It is taken by mouth twice a day. Common side effects include headache, diarrhea, and nausea. Serious side effects include heart problems and bleeding from the stomach. Cilostazol belongs to the class of medications called phosphodiesterase type III inhibitors. It works by blocking the action of phosphodiesterase type III enzymes which increases blood flow through the arteries in the legs.

Claudication is pain or cramping in your leg muscles when you walk due to poor blood circulation. You may have this condition if you have diabetes or peripheral artery disease (PAD).

If you are having trouble walking because of claudication, your doctor may prescribe cilostazol (Pletal). Cilostazol helps improve blood circulation in your legs so that you can walk farther without pain.

Common side effects of cilostazol include headache, diarrhea and nausea.

Serious side effects associated with cilostazol use can include heart problems such as chest pain (angina) and irregular heartbeat (arrhythmia), as well as bleeding from inside your stomach.

Is pletal the same as cilostazol?

This can help people who have problems with walking or leg pain. Pletal works by preventing blood clots from forming and helps keep the blood flowing smoothly.

This medication comes as a tablet that is taken twice a day, with or without food. It is important to take this medication exactly as prescribed by your doctor. Do not stop taking Pletal without talking to your doctor first, as this could cause dangerous side effects.

Some common side effects of Pletal include headache, diarrhea, and nausea/vomiting. However, these symptoms usually go away after a while and do not require any special treatment. Contact your doctor if you experience any severe side effects while taking this medication

Is Plavix and Pletal the same thing?

Claudication is pain in the legs or feet that happens when you walk, caused by poor blood flow. Pletal works by widening the blood vessels and improving blood flow.

Pletal has been studied in more than 10,000 people and has been shown to improve walking distance and time in people with claudication. In addition, Pletal may help reduce heart attacks, strokes, hospitalizations for chest pain (angina), and deaths from any cause in these patients.

Pletal can be taken alone or with other medicines prescribed for claudication such as statins (cholesterol-lowering medicines), aspirin, or beta blockers. Pletal should not be used if you have bleeding problems or are taking certain other medicines including anticoagulants (‘blood thinners’) such as warfarin (Coumadin®).

Talk to your doctor about whether Pletal may be right for you.

Can you take Pletal with food?

This condition is caused by a lack of blood flow to the legs, and can cause pain, cramping, and fatigue when walking. Pletal works by improving blood flow to the legs, which can help relieve these symptoms. It is important to note that Pletal should not be taken if you are also taking nitrates for chest pain, as this combination can cause dangerously low blood pressure levels. Pletal may also interact with other medications, so it is important to speak with your doctor before starting treatment.

Specification: Pletal


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