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Eliquis

Eliquis (apixaban) is a new oral anticoagulant that has been recently approved by the FDA.

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Eliquis – Apixaban – 2.5mg/5mg

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  • Disease: Blood Clots / Deep Vein Thrombosis

It is a direct inhibitor of factor Xa, and does not require monitoring of the international normalized ratio (INR). Eliquis has been shown to be non-inferior to warfarin in the prevention of stroke or systemic embolism in patients with atrial fibrillation, and superior to warfarin in reducing bleeding risk. In addition, Eliquis does not require dose adjustment for renal impairment or use of concomitant medications that interact with warfarin.


Frequently asked Questions

Does Eliquis affect your kidneys?

It is used to treat and prevent deep vein thrombosis (DVT), pulmonary embolism (PE), and atrial fibrillation. Eliquis may also be used for other purposes not listed in this medication guide.

Before taking Eliquis, tell your doctor if you have congestive heart failure, kidney disease, liver disease, bleeding problems such as hemophilia or low platelets, a history of stomach ulcers or bleeding, if you are pregnant or plan on becoming pregnant, or if you are breastfeeding. Do not take this medication without telling your doctor if you are taking any other medications including over-the-counter medications and herbal supplements.

Take Eliquis exactly as prescribed by your doctor. Do not take in larger amounts or for longer than recommended. Follow the directions on your prescription label carefully. Swallow the tablet whole with water. Avoid eating grapefruit or drinking grapefruit juice while taking the medication unless otherwise directed by your doctor. Grapefruit can increase the levels of Eliquis in your body and may cause serious side effects.

If you miss a dose of Eliquis, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with regular dosing schedule.. Do not take two doses at once.. Store eliquid at room temperature away from moisture heat light an children..


Are there any food restrictions while taking Eliquis?

Eliquis was approved by the FDA in 2012 for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. In clinical trials, eliquis was found to be as effective as warfarin and had a lower incidence of major bleeding.

Eliquis is typically taken twice daily with food. It should not be used in patients with creatinine clearance less than 15 ml/min or those taking strong P-glycoprotein inhibitors such as amiodarone, quinidine, or verapamil. The most common adverse effects are bleeding and bruising. Eliquis increases the risk of hemorrhagic stroke and should not be used in patients who have had a prior hemorrhagic stroke or transient ischemic attack.

Elquois is an effective alternative to warfarin for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation


Can you eat garlic while taking Eliquis?

Eliquis has been approved for the prevention of venous thromboembolism in adult patients who have undergone elective hip or knee replacement surgery. In addition, Eliquis is also indicated for the treatment and prevention of deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke in patients with atrial fibrillation.

The efficacy and safety of Eliquis was evaluated in two randomized, double-blind clinical trials involving a total of 9,022 adult patients who had undergone elective hip or knee replacement surgery. In both trials, patients were randomized to receive either 2.5 mg of apixaban orally twice daily or 5 mg enoxaparin subcutaneously once daily for 10 to 14 days followed by placebo oral tablets thereafter. The primary endpoint was incidence of symptomatic venous thromboembolic events (VTE) including DVT, PE, and death due to VTE during the period from day 1 through day 42 postoperatively. Results from both trials showed that apixaban was statistically non-inferior to enoxaparin with respect to the incidence of symptomatic VTE events.

In addition, two large Phase III clinical studies were conducted evaluating the safety and efficacy profile of apixaban when used as an ongoing treatment regimen for adults with atrial fibrillation. The AVERROES study enrolled 5187 patients deemed unsuitable for vitamin K antagonist therapy due to increased risk for bleeding while the ARISTOTLE study enrolled 18201 patient s eligible fo r vitamin K antagonist therapy. Patients were randomized 2:1to receive either apixaban 5 mg orally twice daily or warfarin target INR range 2.0–3.0 adjusted accordingTo local practice). Treatment duration ranged from 12 weeks up To 48 months as clinically indicated by physician assessment based on patient’s individual risk factors Apixaba n met all major pre -specified endpoints including first occurrence oF stroke, systemic embolism, cardiovascular death, myocardial infarction ; hospitalization For heart failure; major bleeding event ; intracranial hemorrhage;and gastrointestinal bleed ing requiring transfusion over different time periods studied ranging From 12 weeks up To 4 years


Are there supplements I should avoid when taking apixaban Eliquis?

Eliquis was approved by the FDA in 2012 for prophylaxis of venous thromboembolism in patients undergoing hip or knee replacement surgery. In 2013, it was also approved for the treatment and prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF).

The efficacy and safety of apixaban has been evaluated in several large Phase III clinical trials. The AVERROES study showed that apixaban was noninferior to warfarin for the prevention of stroke or systemic embolism in patients with AF. The ARISTOTLE study showed that apixaban was superior to warfarin for the prevention of stroke or systemic embolism, as well as death from any cause, when used to treat patients with AF. These studies have led to the FDA approval of apixaban for both prophylaxis and treatment of AF-related events.

The most common adverse effects associated with apixaban are bleeding complications. However, these events are typically mild to moderate in severity and can be managed effectively with appropriate medical therapy. As a result, apixaban is an excellent alternative to warfarin for the prevention and treatment of AF-related events.


Do you need to check INR on Eliquis?

It belongs to a class of medications called anticoagulants, which work by thinning the blood. Eliquis is taken orally, in tablet form, twice daily. It can be taken with or without food.

Eliquis is approved by the Food and Drug Administration (FDA) for the prevention of deep vein thrombosis (DVT), a condition in which blood clots form in one or more veins deep within the body, often causing pain and swelling; and for the treatment of pulmonary embolism (PE), a condition in which a clot blocks one or more arteries in the lungs, leading to shortness of breath, chest pain, and other symptoms.

Eliquis may also be prescribed off-label for other conditions not listed here. Always consult with your doctor before starting any new medication.


Can you eat pineapple when taking Eliquis?

It has been shown to be more effective and safer than warfarin in clinical trials.

Eliquis is approved for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment of deep vein thrombosis and pulmonary embolism. Eliquis should not be used in patients with prosthetic heart valves or severe renal impairment (creatinine clearance 15 ml/min).

The most common side effects are bleeding complications, which can occur both during treatment and after discontinuation. Patients taking Eliquis should have regular blood tests to monitor their clotting status.


Can I take fish oil with Eliquis?

It is a direct oral inhibitor of factor Xa, and does not require monitoring of coagulation parameters. Eliquis has been shown to be noninferior to warfarin for stroke prevention in atrial fibrillation, and may have less bleeding risk. There are some concerns about its use in patients with renal impairment, as it is renally cleared.


What vitamins should not be taken with Eliquis?

Eliquis has been shown to be noninferior to warfarin in the treatment of venous thromboembolism and superior to warfarin in the prevention of stroke and systemic embolism in patients with atrial fibrillation. In addition, Eliquis is approved for prophylaxis of deep vein thrombosis following hip or knee replacement surgery.


Can I drink cranberry juice while taking Eliquis?

It is a direct inhibitor of factor Xa, and does not require monitoring of the international normalized ratio (INR). In two large randomized clinical trials, Eliquis was found to be noninferior to warfarin for the prevention of stroke or systemic embolism. There was also a lower incidence of major bleeding with Eliquis compared to warfarin. Based on these findings, Eliquis may be a good alternative to warfarin for patients with atrial fibrillation who are looking for an oral anticoagulant that does not require routine monitoring.


Does Eliquis cause leg weakness?

Eliquis was approved by the FDA in 2012 for prophylaxis of venous thromboembolism (VTE) in adult patients undergoing elective hip or knee replacement surgery. In 2013, it was approved for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE), also in adults.

Eliquis is a novel agent that has some advantages over warfarin, including once-daily dosing, no need for routine coagulation monitoring or dietary restrictions, and a lower risk of bleeding complications. Like all anticoagulants, however, Eliquis can increase the risk of bleeding if used inappropriately. It should not be given to patients with active pathological hemorrhage or who have recently had a stroke or transient ischemic attack


Can you drink coffee on Eliquis?

It is a direct-acting inhibitor of Factor Xa, and does not require monitoring of the prothrombin time. Eliquis is indicated for the prevention and treatment of venous thromboembolic events (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE).

Eliquis has been shown to be noninferior to warfarin for the prevention of VTE in patients with atrial fibrillation, and has a lower risk of major bleeding than warfarin. In addition, Eliquis does not require regular monitoring or dose adjustments like warfarin does.

Because it does not require regular monitoring, Eliquis may be a good option for patients who have difficulty taking their medication regularly or those who are at high risk for bleeding complications. However, because there is limited experience with this drug in certain populations (e.g., pregnant women), caution should be used when prescribing it to these groups


Does Eliquis have to be taken 12 hours apart?

Eliquis was approved by the FDA in 2012 for this indication. In two randomized, double-blind clinical trials comparing Eliquis to warfarin, Eliquis was found to be non-inferior to warfarin with respect to the incidence of stroke or systemic embolism. In addition, major bleeding events were less frequent in patients treated with Eliquis than those treated with warfarin


What should I watch out when taking Eliquis?

In phase III clinical trials, apixaban was found to be noninferior to warfarin for stroke prevention in patients with atrial fibrillation and superior to warfarin for the treatment of venous thromboembolism. The drug has a favorable safety profile and does not require regular monitoring.

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